Findings in Stillbirths Associated with Placental Disease

Karen J. Gibbins; Halit Pinar; Uma M. Reddy; George R. Saade; Robert L. Goldenberg; Donald J. Dudley; Carolyn Drews-Botsch; Alexa Ann Freedman; Lauren M. Daniels; Corette B. Parker; Vanessa Thorsten; Radek Bukowski; Robert M. Silver

doi:10.1055/s-0039-1688472

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2020; 37(07): 708-715
DOI: 10.1055/s-0039-1688472

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Findings in Stillbirths Associated with Placental Disease

Karen J. Gibbins

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon

,

Halit Pinar

²Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island

,

Uma M. Reddy

³Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut

,

George R. Saade

⁴Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

,

Robert L. Goldenberg

⁵Department of Obstetrics and Gynecology, Columbia University School of Medicine, New York

,

Donald J. Dudley

⁶Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, Virginia

,

Carolyn Drews-Botsch

⁷Department of Epidemiology, Emory University, Atlanta, Georgia

,

Alexa Ann Freedman

⁷Department of Epidemiology, Emory University, Atlanta, Georgia

,

Lauren M. Daniels

⁷Department of Epidemiology, Emory University, Atlanta, Georgia

,

Corette B. Parker

⁸RTI International, Durham, North Carolina

,

Vanessa Thorsten

⁸RTI International, Durham, North Carolina

,

Radek Bukowski

⁹Department of Women’s Health, University of Texas at Austin, Austin, Texas

,

Robert M. Silver

¹⁰Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah

› Institutsangaben

Abstract

Objective Placental disease is a leading cause of stillbirth. Our purpose was to characterize stillbirths associated with placental disease.

Study Design The Stillbirth Collaborative Research Network conducted a prospective, case–control study of stillbirths and live births from 2006 to 2008. This analysis includes 512 stillbirths with cause of death assignment and a comparison group of live births. We compared exposures between women with stillbirth due to placental disease and those due to other causes as well as between women with term (≥ 37 weeks) stillbirth due to placental disease and term live births.

Results A total of 121 (23.6%) out of 512 stillbirths had a probable or possible cause of death due to placental disease by Initial Causes of Fetal Death. Characteristics were similar between stillbirths due to placental disease and other stillbirths. When comparing term live births to stillbirths due to placental disease, women with non-Hispanic black race, Hispanic ethnicity, lack of insurance, or who were born outside of the United States had higher odds of stillbirth due to placental disease. Nulliparity and antenatal bleeding also increased risk of stillbirth due to placental disease.

Conclusion Multiple discrete exposures were associated with stillbirth caused by placental disease. The relationship between these factors and utility of surveillance warrants further study.

Keywords

placental disease - stillbirth - placental insufficiency - placental pathology

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Referenzen

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